2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Cytochrome P450

Cytochrome P450

CYPs

Cytochrome P450

Related Products

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Cytochrome p450 comprises a superfamily of heme-thiolate proteins named for the spectral absorbance peak of their carbon-monoxide-bound species at 450 nm. Having been found in every class of organism, including Archaea, the p450 superfamily is believed to have originated from an ancestral gene that existed over 3 billion years ago. Repeated gene duplications have subsequently given rise to one of the largest of multigene families. These enzymes are notable both for the diversity of reactions that they catalyze and the range of chemically dissimilar substrates upon which they act. Cytochrome p450s support the oxidative, peroxidative and reductive metabolism of such endogenous and xenobiotic substrates as environmental pollutants, agrochemicals, plant allelochemicals, steroids, prostaglandins and fatty acids. In humans, Cytochrome p450s are best known for their central role in phase I drug metabolism where they are of critical importance to two of the most significant problems in clinical pharmacology: drug interactions and interindividual variability in drug metabolism.

Cytochrome P450 Isoform Specific Products:

Cytochrome P450 Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-129923
    (R)-Omeprazole sodium
    		Inhibitor
    (R)-Omeprazole sodium is a gastric acid resistant compound with activity to inhibit gastric acid secretion. (R)-Omeprazole sodium is metabolized in vivo, and its metabolism is primarily affected by cytochrome P450 enzymes. The interaction between (R)-Omeprazole sodium and mannitol may affect its bioavailability in formulations. (R)-Omeprazole sodium exhibits reversible direct and metabolism-dependent inhibition of CYP2C19.
    (R)-Omeprazole sodium
  • HY-135334S
    ACP-5862-d4
    		Inhibitor
    ACP-5862-d4 is deuterium labeled ACP-5862. ACP-5862 is a major active, circulating, pyrrolidine ring-opened metabolite of Acalabrutinib with an IC50 of 5.0 nM for Bruton tyrosine kinase (BTK). ACP‐5862 is a weak time‐dependent inactivator of CYP3A4 and CYP2C8. Acalabrutinib is an orally active, irreversible, and highly selective BTK inhibitor, with an IC50 of 3 nM and EC50 of 8 nM[1][2].
    ACP-5862-d<sub>4</sub>
  • HY-E70501
    Human CYP4F3,High-Reductase+b5
    Human CYP4F3, High-Reductase+b5, a recombinant CYP4F3, is a member of the CYP enzyme family. CYP4F3 is an enzyme mainly expressed in polymorphonuclear leukocytes.
    Human CYP4F3,High-Reductase+b5
  • HY-116444
    16(S)-HETE
    		Activator
    16(S)-HETE is an endogenous inhibitor of neutrophil activity and can be used in the study of acute ischemic brain injury.
    16(S)-HETE
  • HY-13632S2
    Exemestane-d3
    		Inhibitor
    Exemestane-d3 is the deuterium labeled Exemestane. Exemestane (FCE 24304) is a selective, irreversible and orally active steroidal aromatase inhibitor with IC50s of 30 nM and 40 nM for human placental and rat ovarian aromatase, respectively. Exemestane can be used for hormone-dependent breast cancer research[1][2].
    Exemestane-d<sub>3</sub>
  • HY-13600R
    Clobetasol propionate (Standard)
    		Inhibitor
    Clobetasol propionate (Standard) is the analytical standard of Clobetasol propionate. This product is intended for research and analytical applications. Clobetasol propionate is a potent and selective CYP3A5 inhibitor with an IC50 of 0.206 μM. Clobetasol propionate has no inhibiting on CYP3A4 or other major CYPs. Clobetasol propionate is a corticosteroid and has the potential for psoriasis and other dermatoses research.
    Clobetasol propionate (Standard)
  • HY-13600S1
    Clobetasol propionate-d5
    		Inhibitor
    Clobetasol propionate-d5 is a deuterium substitute of Clobetasol propionate. Clobetasol propionate is a potent, selective CYP3A5 inhibitor with a IC50 of 0.206 μM and has potential for use in the study of psoriasis and other skin diseases.
    Clobetasol propionate-d<sub>5</sub>
  • HY-E70514
    Human CYP26B1,Low-Reductase
    Human CYP26B1, Low-Reductase, a recombinant CYP26B, is a member of the CYP enzyme family. CYP26B1 is important for the development and differentiation of the central nervous system (especially the hindbrain) and skeletal development.
    Human CYP26B1,Low-Reductase
  • HY-13762
    Tesmilifene
    		Modulator
    Tesmilifene is an antihistamine agent and a chemical sensitizer. Tesmilifene targets cytochrome P450, exhibits hormonal effects on DNA synthesis in MCF-7 cells, and stimulates the tumor growth in mouse/rat models. Tesmilifene overcomes multidrug resistance.
    Tesmilifene
  • HY-E70471
    Human CYP2C8,High-Reductase
    Human CYP2C8, High-Reductase, a recombinant CYP2C8, is a member of the CYP enzyme family and is involved in the metabolism of xenobiotics in the body.
    Human CYP2C8,High-Reductase
  • HY-N0688R
    Linderane (Standard)
    		Inhibitor
    Linderane (Standard) is the analytical standard of Linderane. This product is intended for research and analytical applications. Linderane, isolated from the root of Lindera aggregata, is an irreversible inhibitor cytochrome P450 2C9 (CYP2C9). Linderane has the potential to relieve pain and cramp.
    Linderane (Standard)
  • HY-116214S
    Cyprodinil-d5
    		Inducer
    Cyprodinil-d5(CGA-219417-d5) is the deuterium labeled Cyprodinil (HY-116214). Cyprodinil (CGA-219417) is a broad-spectrum anilinopyrimidine fungicide and an activator of the aryl hydrocarbon receptor. Cyprodinil also has anti-androgenic and androgenic activities. Cyprodinil can inhibit the biosynthesis of methionine in plant-pathogenic fungi and protect fruits and vegetables from a variety of pathogens.
    Cyprodinil-d<sub>5</sub>
  • HY-E70486
    Human CYP2C9,Low-Reductase +b5
    Human CYP2C9, Low-Reductase +b5, a recombinant CYP2C9, is one of the most important cytochrome P450 (CYP) enzymes. Human CYP2C9, Low-Reductase is responsible for drug metabolism reactions that occur in human populations.
    Human CYP2C9,Low-Reductase +b5
  • HY-W014566R
    4-Nitro-3-(trifluoromethyl)phenol (Standard)
    		Inhibitor
    Moxifloxacin (hydrochloride monohydrate) (Standard) is the analytical standard of Moxifloxacin (hydrochloride monohydrate). This product is intended for research and analytical applications. Moxifloxacin (BAY 12-8039) hydrochloride monohydrate is an orally active bacterial inhibitor that is effective against Streptococcus pneumoniae. Moxifloxacin hydrochloride monohydrate can be used in tuberculosis research.
    4-Nitro-3-(trifluoromethyl)phenol (Standard)
  • HY-135331S
    N-Desmethyl-Apalutamide-15N,d4
    		Modulator
    N-Desmethyl-Apalutamide-15N,d4 is the 15N and deuterium labeled isotope of N-Desmethyl-Apalutamide (HY-135331). N-Desmethyl Apalutamide is an active metabolite of Apalutamide. N-Desmethyl Apalutamide is a less potent antagonist of the androgen receptor and is responsible for one-third of the activity of Apalutamide. The formation of N-Desmethyl Apalutamide mediated predominantly by CYP2C8 and CYP3A4. N-Desmethyl Apalutamide is moderate to strong CYP3A4 and CYP2B6 inducer and has an excellent plasma-proteins bound concentration.
    N-Desmethyl-Apalutamide-<sup>15</sup>N,d<sub>4</sub>
  • HY-19833
    CFG920
    		Inhibitor
    CFG920 is an orally active, nonsteroidal, reversible dual CYP17 and CYP11B2 inhibitor. CFG920 has the potential for metastatic castration-resistant prostate cancer research.
    CFG920
  • HY-141547
    Nav1.7-IN-8
    		Inhibitor
    Nav1.7-IN-8 is a potent blockage of NaV1.7 with high selectivity for the inhibition of NaV1.7 over the subtypes hNaV1.1 and hNaV1.5. Nav1.7-IN-8 inhibits CYP2C9 and CYP3A4 with an IC50 of 0.17 μM and 0.077 μM, respectively. Nav1.7-IN-8 displays significant analgesic effects in rodent models of acute and inflammatory pain.
    Nav1.7-IN-8
  • HY-N0382R
    Galangin (Standard)
    		Inhibitor
    Galangin (Standard) is the analytical standard of Galangin. This product is intended for research and analytical applications. Galangin (Norizalpinin) is an agonist/antagonist of the arylhydrocarbon receptor. Galangin (Norizalpinin) also shows inhibition of CYP1A1 activity.
    Galangin (Standard)
  • HY-E70490
    Human CYP3A5,Low-Reductase +b5
    Human CYP3A5, Low-Reductase +b5, a recombinant CYP3A5, is a member of the CYP enzyme family. CYP3A5 is mainly expressed in the prostate and the liver.
    Human CYP3A5,Low-Reductase +b5
  • HY-159176
    Antitumor agent-183
    		Substrate
    Antitumor agent-183 (compound 3f) has antitumor activity with metabolic stability. Antitumor agent-183 inhibits cancer cell growth, with IC50s less than 5 nM for A549, HCT116, and HS578T cells. The albumin-bound nanoparticle formulation of Antitumor agent-183 has prolonged retention in the tumor tissues.
    Antitumor agent-183
Cat. No. Product Name / Synonyms Application Reactivity
Cytochrome P450 Isoform Comparison

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